Engineering NADPH-dependent oxyfunctionalization in cyanobacteria

Fellow: ESR4
Home Institution: Aix Marseille University – France
Academic Secondment: Graz University of Technology – Austria
Industrial Secondment: Subitec GmbH – Germany


This research will focus on the identification of novel Baeyer-Villiger MonoOxygenases for light-catalyzed whole-cell monooxygenation in cyanobacteria; and the comparison of several BVMOs (kinetic parameters, NADH or NADPH preference, stability in cyanobacteria) to select the most appropriate one and comparison of promoters to modulate enzyme activity in order to get a balanced NADPH/NADP+ consumption; and the Optimization of external O2-supply.